Alnylam is pioneering RNAi therapeutics and scaling rapidly across research, development, and global commercialization. The Director, Cyber Defense Principal Engineer will play a critical role in designing and advancing our next-generation cyber defense capabilities, shaping how we detect, investigate, and respond to threats at scale.

Reporting to the Senior Director, Cyber Defense, this senior individual contributor will define and execute the technical strategy to modernize and future-proof Alnylam’s security platforms. This role will lead the evolution of cyber operations technology, build scalable solutions, and drive enterprise-wide initiatives that strengthen the security and resilience of our systems and data.

This is ahybrid position, primarily based in Cambridge, MA and includes participation in an on-call rotation, with flexibility to support incident response outside standard business hours, as needed.

Responsibilities

• Define and execute the long-term strategy and technical roadmap for Alnylam’s cyber defense capabilities.
• Architect and scale core security platforms, including SIEM/SOAR, security data pipelines, automation frameworks, and detection infrastructure.
• Lead enterprise detection engineering, delivering advanced analytics and risk-based alerting across cloud, endpoint, identity, network, and SaaS environments.
• Build and integrate a unified cyber defense platform to enhance visibility, automation, and enterprise resilience.
• Establish scalable security standards, architectures, and operating principles across Cyber Defense and enterprise teams.
• Drive an engineering-first approach to detection and response, leveraging automation, AI-enabled workflows, and data-driven decision making.
• Serve as a senior technical advisor to leadership on cyber defense strategy, complex incident response, and enterprise risk.

• 10+ years of experience across core cyber defense disciplines (e.g., security engineering, detection engineering, threat hunting, incident response, vulnerability management, offensive security)
• Strong programming and automation skills (e.g., Python, Go), with experience building custom security tooling, integrations, and detections
• Proven experience leading large-scale SIEM migrations or enterprise security platform transformations
• Deep expertise across modern security technologies (e.g., SIEM, SOAR, EDR/XDR, threat intelligence platforms, cloud security, and security data platforms)
• Hands-on experience applying AI/ML and automation to improve threat detection, investigation workflows, and incident response
• Advanced detection engineering capabilities, including behavioral analytics, threat hunting, and frameworks such as MITRE ATT&CK
• Experience designing or supporting insider threat and advanced monitoring programs
• Strong knowledge of vulnerability management, exposure reduction, and risk-based prioritization
• Excellent communication and influencing skills, with the ability to partner across engineering, infrastructure, legal, compliance, and business leadership teams
• Experience operating in complex, global enterprise environments

LI-MH1 #LI-Hybrid

$199,800.00 - $270,300.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We’re proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.