Director, Platform Infrastructure

The Director, Platform Infrastructure will lead Alnylam’s enterprise infrastructure platform strategy, building the secure, resilient, and scalable technology foundation that supports enterprise applications, data and AI, Science, laboratories, Manufacturing, facilities, and critical business operations.

This leader will define and execute a multi-year roadmap for platform infrastructure, including cloud services, hosting, storage, data protection, observability, automation, lifecycle management, resiliency, and cloud financial management. The role will lead a team of architects, engineers, and platform/product owners and will govern managed service providers and strategic technology partners to deliver durable, scalable platform capabilities.

The ideal candidate brings deep technical expertise, strong enterprise leadership, and financial discipline, with the ability to translate complex infrastructure strategy into practical business outcomes that improve reliability, speed, security, and scalability across Alnylam.

This is a hybrid role and will primarily be based in Cambridge, MA.

Responsibilities

• Define and execute the enterprise platform infrastructure strategy and multi-year roadmap across public cloud, on-premises hosting, storage, data protection, observability, automation, lifecycle management, and FinOps.
• Evolve infrastructure services into a platform engineering model that delivers standardized, reusable, automated, and self-service capabilities, including Infrastructure as Code, policy-as-code, platform patterns, and architectural guardrails.
• Own the architecture, engineering, and lifecycle of secure, resilient, and scalable hybrid cloud and on-premises platforms supporting enterprise applications, Science, Manufacturing, laboratories, facilities, data, AI, and regulated OT environments.
• Partner with Manufacturing, Facilities, Quality, Cybersecurity, laboratory technology, automation, and OT engineering teams to align platform services with validated-state, data-integrity, change-control, security, and business-continuity requirements.
• Set enterprise standards for availability, recoverability, observability, capacity, disaster recovery, backup, cyber recovery, technical debt management, lifecycle planning, SLOs, SLIs, and operational health measures.
• Lead cloud financial management and FinOps practices, including tagging, allocation, budgeting, forecasting, cost transparency, optimization, unit economics, and financial accountability for cloud consumption.
• Build and lead a high-performing infrastructure platform organization across cloud, infrastructure, storage, data protection, observability, automation, and platform engineering.
• Govern managed service providers, cloud providers, infrastructure vendors, and technology partners while retaining internal ownership of strategy, architecture, engineering standards, and platform direction.
• Manage operating and capital budgets, cloud consumption forecasts, modernization investments, lifecycle roadmaps, capacity plans, and vendor strategies that improve scalability, reliability, security, performance, and financial sustainability.

• Bachelor’s degree in computer science, information technology, engineering, or a related field required; advanced degree preferred.
• 12+ years of progressive experience across enterprise infrastructure, cloud, hosting, storage, data protection, observability, automation, FinOps, or platform engineering, including 5+ years leading infrastructure engineering, architecture, cloud, technical operations, or platform teams.
• Demonstrated experience defining and executing infrastructure, cloud, or platform transformation strategies within a complex global enterprise environment.
• Strong technical understanding of public and hybrid cloud, compute, virtualization, operating platforms, storage, backup, disaster recovery, cyber recovery, observability, automation, identity integration, networking, and infrastructure security controls.
• Experience establishing cloud platforms and governance, including landing zones, account structures, platform guardrails, Infrastructure as Code, automation, policy-as-code, and self-service capabilities within AWS, Azure, or comparable hyperscale environments.
• Experience supporting or partnering with teams responsible for regulated OT, laboratory, Manufacturing, facilities, automation, or validated environments; biotechnology, pharmaceutical, life sciences, manufacturing, or other regulated industry experience preferred.
• Experience with cloud financial management, FinOps, budgeting, forecasting, capital planning, vendor management, technology investment governance, and managed service provider oversight.
• Strong executive communication, stakeholder management, and influencing skills, with the ability to translate complex platform strategies into clear business outcomes.

$186,400-$252,200 paid time off United States, Massachusetts, Cambridge Sep 22, 2026, The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We’re proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.