Staff Site Reliability Engineer

• We will rely on you to architect, tune and operate multi-tenant ClickHouse or equivalent OLAP database clusters at multi-trillion-row, petabyte scale.
• You will own SLOs, observability, capacity planning and incident response for data-intensive systems and pipelines, as well as the orchestration and job execution that support them.
• You will shape Data-as-a-Service as a product, including secure multi-tenant immutable releases and catalogue and ontology-driven discoverability.
• You will power agentic AI from the data platform by scaling the data foundations behind MystraAI and owning secure, tenant-scoped access for agents.
• You will treat security as a first-class architectural concern, including tenant isolation, secrets and credential management, and least-privilege access to systems, tools and data.
• You will set technical direction, mentor and line-manage a small team of IC2/IC3 engineers, and influence decisions beyond your immediate team.

Technologies:

• Agentic AI
• AI
• Architect
• ClickHouse
• Support
• Security

• We are looking for a recognised specialist who leads through expertise, with principal-level individual contributor depth and the judgement to set standards others follow.
• We need deep experience designing and tuning multi-tenant ClickHouse at extreme scale, including working with the engine at source level and ideally contributing code upstream.
• We value true SRE discipline for data platforms, including SLOs, observability, capacity planning and incident response for analytical data systems and pipelines.
• We are looking for experience productising data as a secure, multi-tenant, immutable release with discoverability at scale.
• We need understanding of how to expose platform data to agents safely and at scale, including access patterns, tenant isolation and guardrails.
• We require strong multi-tenant security design experience, including isolation, least-privilege access and secrets management.
• We are looking for technical leadership experience, including mentoring engineers and line-managing a small team while staying hands-on.

We are Genomics, a science-led transatlantic TechBio combining large-scale genetic and health data with proprietary analytics to accelerate drug discovery and advance predictive, preventative healthcare. Our mission is to help people live longer, healthier lives by super-charging drug discovery with our AI-enabled advanced genetic analytics platform and by helping people understand their personal risk of common chronic diseases through polygenic risk scores. This is a Staff-level hybrid role based in Oxford or London, focused on our analytical data platform Mystra and the MystraAI layer built on top of it. We offer competitive, externally benchmarked compensation, a clear career path, continuous learning, 25 days annual leave plus bank holidays and an additional year-end shutdown, a market-leading pension, comprehensive private health insurance for you and your family with no excess, critical illness cover, life assurance, enhanced family leave, flexible hybrid working from our London or Oxford offices, inclusive time off, a vibrant social culture and a cycle-to-work scheme.

last updated 39 week of 2026