Principal Software Engineer

The Regeneron Genetics Center is one of the largest human genetics sequencing programs in the world. We study human DNA at massive scale to understand why diseases happen and how we can stop them. Using genetics to improve human health, our research has contributed directly to medicines helping patients today.

The RGC IT team builds and maintains shared services, platform tooling, and APIs that our research teams depend on. We approach development with an AI-first mindset, utilizing LLM-powered tooling to move faster, explore more ideas and quickly turn complex problems into working solutions for our scientists.

A Typical Day As a Principal Software Engineer, youll contribute to:

• API and service development across a shared platform that research teams use to access and work with large-scale genetic data.
• Cloud-based data pipeline work on AWS, keeping high-volume genomic data moving reliably and performantly.
• Integrating and applying AI tooling across development workflows from LLM-assisted coding and review to building AI-powered capabilities into the platform itself.
• Working directly with scientists and engineers to understand requirements and deliver meaningful solutions to improve our scientific discovery process.

• Strong fundamentals at the API and data layer. Youve built production APIs, integration services, and pipelines in the cloud as microservices.
• Comfortable with AI-first development. You use tools like Claude Code as a core part of how you work not occasionally, but throughout planning, implementation, and review.
• Technical depth across the stack. API design patterns, distributed systems, cloud-native development on AWS you can contribute without needing everything handed to you.
• Works well as part of a team. Decisions here are collaborative. You do good work in that kind of environment.
• Takes quality seriously. You write things that can be tested and maintained, and you know why that matters at scale.

To be considered for this opportunity, you must have a Bachelors Degree or higher with at least 6 years of relevant IT experience building cloud-native applications. Candidates must have hands-on experience with:

• Languages & Runtimes: Python, TypeScript
• API & Integration: REST API design and development, service integration patterns
• AI Tooling: LLM-assisted development tools (e.g. Claude Code, GitHub Copilot), AI/ML service integration
• Data & Databases: PostgreSQL or MySQL, Redshift or Snowflake, ETL orchestration
• Infrastructure: Docker, AWS cloud services

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other countries specific benefits, please speak to your recruiter.

Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regenerons roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regenerons on-site policy and expectations for your role and your location., Regeneron is a leading biotechnology company that invents, develops, and commercializes life-transforming medicines for people with serious diseases. Founded and led by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to numerous approved treatments and product candidates in development, most of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurological diseases, hematologic conditions, infectious diseases, and rare diseases.