Director of IT Operations

This role owns IT service delivery and vendor operations at Nurix. You will manage our internal service delivery team, oversee our managed service providers, and lead initiatives to improve how IT supports the business. Beyond running day-to-day operations, you will design and evolve Nurix's IT operating model as the company grows.

The goal is not simply to manage vendors, It's to create a service experience where employees get reliable help, problems get solved quickly, and IT enables rather than slows down the work. You're empowered to restructure vendor relationships, change providers, or build internal capability as needed to achieve that outcome.

This is a growth role. In Year 1, the focus is building a strong operational foundation. As that foundation matures, the role expands toward direct engagement with lines of business as an IT strategic partner.

Responsibilities

Service Delivery

• Lead the service delivery function, including the Service Delivery Manager and coordination with MSPs

• Own escalations and ensure employees receive timely, quality support

• Design and improve service delivery processes: documentation, knowledge management, meaningful metrics

• Evolve the operating model over time-assess what should be handled internally vs. through partners

• Manage on-prem infrastructure through MSPs; build internal capability if and when it makes sense

Vendor Operations

• Own vendor relationships across the IT service provider portfolio
• Set clear expectations: scope, performance standards, accountability
• Lead contract negotiations and renewals to improve value
• Ensure vendors build our capability-we want to learn, not become dependent
• Rationalize the vendor portfolio as needed to improve outcomes

Planning & Programs

• Develop a technology roadmap aligned with Nurix's clinical and business milestones, including sequencing and tradeoff rationale to support leadership decision-making
• Help leadership prioritize initiatives-frame options, clarify tradeoffs, recommend paths forward
• Lead cross-functional projects spanning infrastructure, security, and applications
• Support budget development, expense tracking, and financial reporting

Collaboration

• Coordinate with Information Security on system hardening and compliance
• Work with Cloud Infrastructure on AWS and cloud-first initiatives

• 10+ years in IT, including 5+ years in leadership or management roles
• Experience managing vendor relationships: contracts, performance, accountability
• Background in biotech, pharma, or life sciences
• Track record building roadmaps and driving cross-functional alignment
• Strong at translating business needs into actionable plans
• Effective communicator across technical and scientific audiences
• Bachelor's degree in a technical field, or equivalent experience

Preferred

• Familiarity with GxP and regulated IT environments
• Experience with research platforms (ELN, LIMS, scientific data systems)
• AWS or cloud platform experience
• Product management or digital strategy background
• Coordinate with Information Security on system hardening and compliance
• Work with Cloud Infrastructure on AWS and cloud-first initiatives

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Ability to function in a dynamic environment
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease., Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.