Development of methods

Development of methods for cryo-EM image analysis and protein docking to elucidate binder-induced conformational changes (PhD cotutelle with the University of Melbourne) Champs scientifiques

• Informatique
• Biologie
• Physique

• Master 2 in computer science, bioinformatics, biophysics, or a related field
• Strong theoretical foundations and practical skills in at least two of the following areas: AI/ML, image processing, molecular modeling and docking
• Strong experience in Python and C++ programming (knowledge of Fortran is a plus)
• Strong interest in interdisciplinary research bridging computer science, physics, and biology
• Excellent oral and written communication skills
• Strong organizational skills, autonomy, and efficiency
• Commitment to quality and rigor in work
• Analytical and conceptual skills
• Good interpersonal skills and team spirit
• Availability for a one-year stay at the University of Melbourne (second year of the PhD)
• Candidates must meet the PhD admission requirements of both universities: Sorbonne University and the University of Melbourne. University of Melbourne entry requirements: First Class Honours (H1) or equivalent (~80%; excellent Master 2, top 10%), and English language requirements.

The PhD student will be co-supervised by a researcher from Sorbonne University (regarding the computational method development) and a researcher from the University of Melbourne (regarding the application of the new methods to VCP/p97 data). This is a joint PhD thesis between Sorbonne University and the University of Melbourne, with a mandatory one-year stay at the University of Melbourne (during the second year of the PhD). At Sorbonne University, the student will join IMPMC-UMR 7590 (https://impmc.sorbonne-universite.fr/en). At the University of Melbourne, the student will join the Bio21 Molecular Science & Biotechnology Institute (https://www.bio21.unimelb.edu.au). As this is a joint PhD program between Sorbonne University and the University of Melbourne, candidates must meet the doctoral admission requirements of both universities. For international applicants to the University of Melbourne, this generally corresponds to a very high academic level (often around 80% of the maximum grade, or equivalent depending on the grading system). In the French system, this generally corresponds to an excellent Master 2 performance, ranking among the top 10% of the class.