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The U.S. Oncology business within our company is a growing and dynamic organization committed to advancing innovative therapies for patients with cancer. We have an exciting opportunity to join our dynamic commercial team as we prepare for the potential U.S. launch of an mRNA-based individualized neoantigen therapy for early-stage melanoma, being developed through an alliance partnership. This novel product has the potential to redefine personalized cancer treatment and requires a highly coordinated operating model to support seamless therapy delivery across a complex treatment ecosystem.

Reporting to the Executive Director, U.S. Oncology Marketing, Moderna Alliance , the Director, Individualized Therapy Operations serves as the U.S. commercial leader accountable for the strategy, design, and execution of the product end- to-end operational ecosystem , ensuring a seamless, and scalable process t o suppo rt this individu alize d therap y product.

This leader will oversee the operational strategy, capabilities, processes, and governance across the Intismeran operational ecosystem to ensure seamless coordination and integration across sample and tissue operations, logistics coordination, manufacturing demand planning, operational performance management, and customer support. The role will coordinate across our company, alliance partner, sequencing providers, distributors, and treatment sites to ensure reliable therapy delivery and treatment completion.

As the commercial owner of the end-to-end operational ecosystem , this individual will lead the development of the capabilities, governance, and operational infrastructure required to support launch readiness, commercial scale, and future growth. The role will also oversee the organization responsible for centralized coordination, partner management, capacity planning, analytics, and operational excellence.

Key Responsibilities

• Serve as the US commercial owner of the Intismeran end-to-end operational ecosystem, accountable for designing, integrating, and optimizing the capabilities, processes, and stakeholder interactions required to support a seamless, scalable, and compliant treatment journey from order through treatment administration.

• Define and lead the end-to-end operational strategy and governance framework required to support launch readiness, commercial execution, future growth, and long-term scalability, including governance, operating cadence, escalation pathways, and performance standards.

• Own the Intismeran orchestration ecosystem , including operational workflows, digital orchestration capabilities, sample and tissue operations, logistics coordination, customer support capabilities, and treatment journey process integration.

• Lead cross-functional alignment across internal and external stakeholders , including Manufacturing, Supply Chain, Precision Medicine, IT, Market Access, Patient Support Programs, Treatment Site Strategy, alliance stakeholders, sequencing providers, distributors, and treatment sites to ensure reliable therapy delivery and treatment completion.

• Provide strategic leadership and oversight of the Treatment Site Operations Coordinator (TSOC) capability , ensuring the centralized coordination model, workflows, governance, and performance standards effectively support seamless treatment journey execution across treatment sites, manufacturing, logistics, and internal partners.

• Establish and oversee operational performance management , including enterprise KPIs, service level objectives, dashboards, operational demand planning , capacity planning, risk management, and executive reporting to drive data-based decision making and operational excellence.

• Lead operational governance and control tower activities, proactively identifying and resolving operational barriers, exceptions, and capacity constraints while driving initiatives that improve efficiency, customer experience, and treatment completion.

• Build and evolve future-state capabilities required to support individualized therapies , including scalable operational capabilities, advanced analytics, orchestration technologies, process innovation, and operational readiness for future growth.

• Lead the Intismeran Individualized Therapy Operations organization , including oversight of treatment journey strategy , centralized coordination capabilities, manufacturing demand planning, partner management, and operational excellence, while building the organizational capabilities required to support future scale and growth.

Analytics Operations Leadership Management Governance Innovation Compassion Scalability Coordinating Supply Chain Cell Therapy Communication Data Analysis Biotechnology Accountability Pharmaceuticals Risk Management Problem Solving Market Research Decision Making Demand Planning Customer Service Customer Support Telephone Skills Direct Marketing Digital Marketing Commercialization Capacity Planning Influencing Skills Advanced Analytics Executive Presence Strategic Thinking Business Decisions Workflow Management Process Integration Contingent Workforce Strategic Leadership Management Of Cancer Technology Ecosystems Operations Management Competency Management Performance Management Operational Excellence IT Capacity Management Pre-Clinical Development Service Level Objectives Product Launch Readiness Clinical Trial Development Data-Driven Decision Making Integrated Business Planning Influencing Without Authority Continuous Improvement Process Partner Relationship Management Key Performance Indicators (KPIs) Operational Performance Management Cross-Functional Project Management Master Of Business Administration (MBA), * Bachelor’s degree or equivalent (BA/BS)

• MBA or equivalent preferred

Required Experience and Skills:

• Minimum of 8 years of experience in biotechnology, pharmaceuticals, healthcare, or related industries, including leadership experience in complex therapy operations or operational strategy roles .

• Demonstrated success designing and leading complex operating models that require coordination across multiple internal functions and external partners to deliver seamless customer and patient experiences.

• Proven ability to lead cross-functional initiatives and influence senior stakeholders across various stakeholders including commercial, manufacturing, supply chain, market access, IT, and external partner organizations.

• Experience building and scaling operational capabilities, including governance structures, operating procedures, customer support models, orchestration platforms, analytics, and performance management systems.

• Strong strategic thinking and problem-solving capabilities, with a demonstrated ability to navigate ambiguity, resolve complex operational challenges, and translate strategy into execution.

• Experience establishing and managing KPIs, dashboards, capacity planning processes, and operational performance metrics to drive business decisions and continuous improvement.

• Excellent communication and executive presence, with the ability to influence without authority and effectively communicate across all organizational levels.

• Experience leading and developing high-performing teams, fostering a culture of accountability, collaboration, innovation, and operational excellence.

Preferred Skills :

• Experience supporting the commercialization of complex therapies, including, cell therapy, gene therapy, radioligand therapy, or other highly coordinated treatment models.

• Experience with treatment journey orchestration platforms, case management systems, workflow technologies, operational control towers, or customer support ecosystems.

• Experience in manufacturing demand planning, integrated business planning, supply chain operations, or capacity management.

Required Skills: Ability to Coordinate, Ability to Coordinate, Building Capability, Clinical Development, Clinical Reporting, Clinical Trial Development, Commercial Operations Management, Competency Management, Cross-Functional Project Management, Data Analysis, Decision Making, Digital Marketing Campaigns, Direct Marketing, Executive Presence, Healthcare Personnel (HCP) Marketing, Innovation, Liaison Work, Market Access, Market Research, Oncology, Oncology Marketing, Operating Models, Operational Activities, Operational Architecture, Operations Management {+ 10 more}, Valid Driving License, Leadership Management Governance Innovation Compassion Scalability Coordinating Supply Chain Cell Therapy Communication Data Analysis Biotechnology Accountability Pharmaceuticals Risk Management Problem Solving Market Research Decision Making Demand Planning Customer Service Customer Support Telephone Skills Direct Marketing Digital Marketing Commercialization Capacity Planning Influencing Skills Advanced Analytics Executive Presence Strategic Thinking Business Decisions Workflow Management Process Integration Contingent Workforce Strategic Leadership Management Of Cancer Technology Ecosystems Operations Management Competency Management Performance Management Operational Excellence IT Capacity Management Pre-Clinical Development Service Level Objectives Product Launch Readiness Clinical Trial Development Data-Driven Decision Making Integrated Business Planning Influencing Without Authority Continuous Improvement Process Partner Relationship Management Key Performance Indicators (KPIs) Operational Performance Management Cross-Functional Project Management Master Of Business Administration (MBA) +0

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The salary range for this role is $190,800.00 - $300,300.00

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.