Backend Application Engineer

Manifest is hiring a highly qualified, Senior+ backend software engineer responsible for designing and scaling new and existing web services and ETL architecture to support hundreds of thousands of transactions per second. This role will drive high-performance, resilient system designs in a fast-paced, data-intensive environment. The impact you will have:

• Architect and build robust, fault-tolerant web and ETL services that scale to high throughput.
• Act as a key communicator, bridging gaps between teams, clarifying technical concepts, and ensuring alignment across projects.
• Identify and implement improvements in system performance and processes, ensuring the company remains competitive in a fast-paced market.
• Design and build new features for the Manifest platform to be used by critical organizations around the world.

As a Senior Backend Engineer - Product & Platform:

• Architect and implement scalable web services and ETL pipelines
• Design high-performance systems that efficiently handle 10K’s+ transactions/sec
• Collaborate with engineering teams to optimize existing systems and integrate new technologies
• Develop robust monitoring, testing, and deployment strategies for mission-critical services
• Define and maintain the high standards of our engineering culture. As a part of a high performing engineering team, you’ll help recruit and onboard your colleagues
• Work closely with product management, designers, and other engineers
• Resolve issues together quickly and collaboratively
• Communicate internally and externally on what we’re building and why it’s special, Leads business development and strategic account growth with pharmaceutical and biotechnology partners across the U.S. West and Central regions. Responsibilities include acquiring customers, building pipelines in Salesforce, developing proposals, advancing precision medicine and genomics opportunities, negotiating and closing projects, and collaborating with scientific, commercial, and operational teams. The role focuses on NGS-based assays, biomarker discovery, clinical trial solutions, and companion diagnostics, with approximately 30% domestic and international travel. Top Skills: Biomarker DiscoveryClinical Trial AssaysCompanion Diagnostics (Cdx)CtdnaGenomic AssaysLiquid BiopsyNext-Generation Sequencing (Ngs)SalesforceSophia Ddm T-Mobile

• 8+ years of experience in software engineering, with a focus on web services and ETL systems
• Proven track record scaling high-volume, data-intensive systems
• Expertise in distributed systems, microservices, and cloud architectures
• Familiarity with containerization, orchestration, and CI/CD pipelines
• High proficiency in our primary stack (TypeScript, Mongo, Go, Python) is not strictly required, but you should be familiar enough to be able to quickly spin up on languages applicable to your role.
• Previous experience with commercial software products (SaaS and on-prem) that support 3rd party/external customers.
• Experience working in early-stage technology (B2B SaaS) startups
• Strong communication skills and the ability to work effectively in a collaborative environment

Bonus but not required:

• Strong experience with MongoDB in particular and other data stores as well
• Experience with or general familiarity with AI/ML, LLMs, & model tuning
• Background or experience in infosec, red teaming, or broader cybersecurity concepts
• Experience with other FOSS and Commercial SDLC security and DevSecOps tooling, including SCA, DAST, SAST, etc.

Salary: $150,000 - $210,000/year + meaningful stock options. Placement within the range depends on experience and skills.

• Help organizations get newfound visibility into their software and be more secure!
• Fully remote work (with potential for hybrid co-working)
• Unlimited PTO (which we take seriously)
• Medical/dental/vision insurance coverage for you and your dependents is paid at 100%!
• Competitive salary & meaningful stock options
• 401(k) and retirement options
• ️ Help get in at the ground floor of a well-funded, early-stage startup!
• Additional benefits to come (retirement, holiday gifts, etc.), Remote 4 Locations 120K-216K Annually Expert/Leader 120K-216K Annually Expert/Leader Other * Utilities Senior enterprise sales leader responsible for winning Fortune 1000 new logos and expanding strategic accounts. Build C-suite relationships, architect tailored technology solutions, lead complex multi-stakeholder deals, manage pipeline and forecasting via CRM, and coordinate cross-functional execution for global, high-value clients. Top Skills: CRM PNC Bank, 41K-83K Annually Mid level 41K-83K Annually Mid level Machine Learning * Payments * Security * Software * Financial Services Provides enterprise technology support through phone, ticketing, and potentially chat channels. Troubleshoots hardware, software, network, access, and application issues; manages incidents and escalations; documents resolutions in ServiceNow or similar ITSM tools; analyzes trends and operations data; supports knowledge management, training, process improvement, and automation; and coaches junior analysts while maintaining customer service, security, and confidentiality standards. Top Skills: Call Center TechnologiesHardware InfrastructureItsmNetworkingServicenow

What you need to know about the Colorado Tech Scene

With a business-friendly climate and research universities like CU Boulder and Colorado State, Colorado has made a name for itself as a startup ecosystem. The state boasts a skilled workforce and high quality of life thanks to its affordable housing, vibrant cultural scene and unparalleled opportunities for outdoor recreation. Colorado is also home to the National Renewable Energy Laboratory, helping cement its status as a hub for renewable energy innovation.

Key Facts About Colorado Tech

• Number of Tech Workers: 260,000; 8.5% of overall workforce (2024 CompTIA survey)
• Major Tech Employers: Lockheed Martin, Century Link, Comcast, BAE Systems, Level 3
• Key Industries: Software, artificial intelligence, aerospace, e-commerce, fintech, healthtech
• Funding Landscape: $4.9 billion in VC funding in 2024 (Pitchbook)
• Notable Investors: Access Venture Partners, Ridgeline Ventures, Techstars, Blackhorn Ventures
• Research Centers and Universities: Colorado School of Mines, University of Colorado Boulder, University of Denver, Colorado State University, Mesa Laboratory, Space Science Institute, National Center for Atmospheric Research, National Renewable Energy Laboratory, Gottlieb Institute

Manifest is on a mission to secure the global software and AI supply chain. Our platform automates the discovery and analysis of risks across internally built and third-party software and AI systems, giving security, product, and engineering teams complete visibility into the components and dependencies that make up their technology stack. From product security and AI risk to supplier risk and compliance, we help teams trust the software and AI they build and buy.

Founded by alumni from the Department of Defense, CISA, and Palantir, Manifest is backed by leading investors including Ensemble VC, First Round Capital, Homebrew, BoxGroup, XYZ Venture Capital, AE Ventures, Leap435, and Overmatch VC. The company partners with the US Air Force, DHS, Global 2000 companies, and critical infrastructure organizations across defense, automotive, and financial services to bring transparency, resilience, and trust to modern digital systems.