Senior / Principal Machine Learning Scientist

• Pioneer novel machine learning methodologies and statistical frameworks (e.g., generative models, causal inference, diffusion models, and advanced transformer architectures) to address fundamental challenges in cell health and rejuvenation
• Contribute to setting the long-term technical vision and research strategy for a core domain (e.g., multi-modal data fusion, perturbation modeling) within the Institute of Computation
• Translate your deep understanding of the mathematical and theoretical underpinnings of cutting-edge AI research into high-impact applications
• Design, implement, and optimize large-scale machine learning systems using modern frameworks (e.g., PyTorch, JAX) and agile practices
• Develop and manage efficient distributed training strategies across multiple GPUs and compute clusters to handle terabytes of multi-modal biological data
• Develop robust approaches for multi-modal data integration and cross-domain mapping to extract actionable biological insights
• Apply computational thinking to solve problems in drug target identification, compound assessment, and prediction of cellular perturbation responses
• Lead the full ML development lifecycle from theoretical conception and data strategy through model development, training, and evaluation
• Act as a key technical mentor to Machine Learning Scientists and Engineers, raising the bar for scientific rigor and model robustness across the organization.

As a Senior or Principal Machine Learning Scientist, you will play a prominent role in developing generative AI/ML models for multi-modal, multiscale biology from virtual cells to agentic target assessment. We are looking for a hands-on, creative, and collaborative individual to join our multidisciplinary team of scientists and engineers focused on transforming how we treat aging and disease. The successful candidate will thrive in a fast-paced environment that emphasises teamwork, transparency, scientific excellence, originality, rigor, and integrity., * Proven track record leveraging machine learning to solve real-world problems;

• Expertise in one or more of the following: generative models, language models, computer vision, bayesian inference, causal reasoning & inference, transfer & multi-task learning, diffusion models, graph neural networks, active learning, cooperative agents
• Experience writing production-quality code with modern machine learning frameworks such as PyTorch, TensorFlow, JAX, or similar
• Experience with multi-GPU and distributed training at scale
• A team player who thrives in collaborative environments and is committed to enabling colleagues to reach their full potential through giving and requesting feedback focussed on professional growth
• Able to advise others across the wider function / company on cutting edge practices and approaches to enable the science / research. Desire to constantly expand your skillset and knowledge. Keen to learn more about biology, computational science, and medicine;
• Inspired by the Altos mission of restoring cell health and resilience to reverse disease, injury, and age-related disabilities., * Ph.D. in Machine Learning, Computer Science, Artificial Intelligence, Statistics, or a related quantitative field, demonstrating a deep theoretical foundation in ML/AI.
• 6+ years of of relevant post-PhD work experience in either an academic or industry setting
• Proven experience developing and applying complex machine learning models, preferably with a significant portion of that time spent in a fast-paced industry or translational research environment.
• A strong track record of leading and publishing innovative, peer-reviewed research in top-tier ML conferences (e.g., NeurIPS, ICML, ICLR) or high-impact scientific journals.
• Excellent scientific communication skills: verbally and in writing; with computational and non-computational audiences, in informal 1-1 settings, team meetings, and formal seminars
• Expertise in several of the following: deep learning, reinforcement learning, generative models, language models, computer vision, Bayesian inference, causal reasoning & inference, transfer & multi-task learning, graph neural networks, active learning, hybrid mechanistic/ML models
• Proven experience applying sophisticated ML techniques to molecular and cell biological data sets (e.g., NGS, spatial omics, bioimaging)., * Experience in cell health and rejuvenation related research area
• Experience in the application of machine learning methods to biological data
• Experience in computational approaches to drug discovery
• Experience with software development methodologies and open-source software

We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment.