Postdoctoral Position: Mechanotyping of Complex Cellular Systems

You will work at the interface of mechanobiology, nanotechnology, systems biology, and quantitative biology, developing and applying innovative experimental and analytical approaches to characterize cellular mechanical states and their regulatory roles. Research directions include:

• Quantitative mechanotyping of single cells, tissues, and multicellular systems (e.g., organoids, spheroids)
• Development and application of nanotechnological platforms for force sensing, manipulation, and mechanical phenotyping
• Advanced cell biological techniques, including live-cell imaging, super-resolution microscopy, and genetically encoded reporters
• Systems biology approaches to integrate mechanical phenotypes with molecular, signaling, and transcriptional networks
• Quantitative modeling and data-driven analysis of multi-parameter cellular states
• High-throughput and multi-scale approaches to link mechanical properties to functional cellular outcomes

The position offers substantial freedom to shape novel experimental pipelines that bridge physical measurements with systems-level biological insight. Independent working on an interdisciplinary challenging and complex project at highest scientific levels at the Department of Biosystems Science and Engineering, ETH Zürich in Basel in collaboration with internationally leading groups in cell, organoid and computational biology.

• PhD degree or equivalent in the fields of cell biology, mechanobiology, bionanotechnology, systems biology, quantitative biology (phenotyping), computational biosystems analysis, and other related disciplines
• Experience in human and animal cell biology, cellular systems, and organoids
• Expertise in micro-/nanofabrication, advanced optical microscopy and nanooscopy, image analysis, computational analysis
• Interest in getting trained in molecular and cellular biophysics, bionanotechnology, cell and tissue biology, high end optical microscopy, phenotyping, multiplexing
• Interest in interdisciplinary research at the ETH Zurich in Basel with cell biology, organoid biology, nanotechnology, mechanobiology, computational biology and biophysics is welcome
• Ability to work independently as well as part of a team
• Excellent organizational skills and high reliability
• Excellent track record in scientific working, communication, and publishing
• Outstanding ability to work independently in highly collaborative teams
• Fluent oral and written communication skills in English are essential

• Exciting and highly innovative and collaborative research within the framework of the Department of Biosystems Science and Engineering at the ETH Zurich in Basel
• Highly interdisciplinary and collaborative research environment
• Full access to state-of-the-art nanofabrication facilities and expertise at the campuses of ETH Zurich
• Support benefits (networking, career development)
• Regular seminars and symposia at ETH Zurich and Basel ecosystem
• Fully funded position for initially 1-2 years, with the possibility of extension contingent on performance and funding

Working, teaching and research at ETH Zurich

ETH Zurich is one of the world's leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.