Senior Data Scientist

• Design, implement, and validate Monte Carlo simulation models for clinical trial outcome prediction, enrolment forecasting, and risk quantification.

• Develop predictive and prescriptive analytics solutions (survival analysis, time-series forecasting, causal inference) using real-world data (RWD), electronic health records, and claims data.

• Build Bayesian hierarchical models for adaptive trial design, interim analysis support, and

probability-of-success estimation.

• Create reproducible ML pipelines (feature engineering, model training, hyperparameter tuning, deployment) on cloud platforms (AWS, GCP, or Azure).

• Partner with biostatistics and clinical teams to translate statistical findings into protocol amendments, site-selection strategies, and regulatory submissions.

• Develop interactive dashboards and data products (Streamlit, Shiny, or Tableau) that communicate model outputs to non-technical stakeholders.

• Conduct sensitivity analyses and scenario planning to quantify uncertainty in drug-development timelines and portfolio investment decisions.

• Mentor junior data scientists and contribute to internal best practices, code reviews, and

knowledge-sharing sessions.

• Master's or Ph.D. in Statistics, Biostatistics, Data Science, Applied Mathematics, Computational Biology, or a related quantitative discipline.

• 5-8 years of hands-on experience building predictive models in a healthcare, pharma, or biotech setting.

• Strong proficiency in Python (NumPy, SciPy, pandas, scikit-learn, PyMC / Stan) and/or R.

• Demonstrated expertise in Monte Carlo methods (MCMC, importance sampling, bootstrapping) and stochastic simulation.

• Experience with survival analysis (Cox PH, Kaplan-Meier, competing risks) and longitudinal/

mixed-effects models.

• Working knowledge of clinical trial design (Phase I-IV), ICH-GCP guidelines, and regulatory data standards (CDISC, SDTM, ADaM).

• Proficiency with SQL and cloud-based data infrastructure (Snowflake, Redshift, BigQuery, Databricks).

• Excellent communication skills with the ability to present complex quantitative results to clinical, regulatory, and executive audiences.