Lead Proteomics Scientist

This role will lead the development of advanced proteomics workflows, support collaborative research programs, and expand the university’s mass spectrometry capabilities. The successful candidate will work closely with investigators across multiple disciplines to design experiments, generate high-quality data, and advance impactful research initiatives.

What You’ll Do

• Develop and implement discovery, quantitative, targeted, and specialized proteomics workflows
• Design and optimize LC-MS/MS methods and data analysis pipelines
• Operate, maintain, and troubleshoot advanced mass spectrometry instrumentation
• Conduct proteomics experiments, including sample preparation and quantitative analyses
• Consult with investigators on study design, analytical strategies, and data interpretation
• Support manuscript preparation, grant applications, and collaborative research efforts
• Evaluate emerging technologies and incorporate new approaches into core services
• Maintain quality control standards, laboratory compliance, and operational excellence

• Expertise in LC-MS/MS-based proteomics and quantitative proteomics methodologies
• Experience with high-resolution mass spectrometry platforms and proteomics data analysis software
• Strong background in experimental design, data interpretation, and scientific collaboration
• Experience supporting multidisciplinary research teams and managing multiple projects simultaneously
• Excellent communication and scientific writing skills
• Commitment to advancing research through innovative technologies and best practices

Minimum Requirements

• Ph.D.
• 5+ years of related experience, Experience developing and executing quantitative proteomics data analysis workflows using standard software tools.

Strong record of scientific achievement demonstrated through peer-reviewed publications arising from collaborative proteomics projects.

Excellent communication skills and a demonstrated commitment to supporting a diverse research community across disciplines.

Ability to manage multiple concurrent projects, maintain accurate records, and meet deliverable timelines across a diverse investigator user base.

Familiarity with NIH Genomic Data Sharing Policy, HIPAA-compliant handling of human research samples, and relevant IRB considerations.

Experience with long-read or top-down proteomics approaches, or multi-omics data integration.

Experience developing or contributing to cost-recovery pricing structures for core facility services. Does this position have supervisory responsibilities? No Preferred Education/Experience Minimum of 5 years of proteomics experience beyond the Ph.D. (e.g., post-doctoral research, industry scientist role, or academic core facility position). Demonstrated expertise in LC-MS-based proteomics, including hands-on experience with modern Orbitrap or equivalent high-resolution mass spectrometry platforms.

Experience with Thermo Scientific instrumentation, including Orbitrap Exploris, Ascend, and Altis platforms. Proficiency in at least three major proteomics workflow types: discovery proteomics (DDA and/or DIA), quantitative proteomics (TMT, SILAC, or LFQ), targeted proteomics (PRM/MRM), or PTM analysis.

• Scientific leadership: Help shape the future of proteomics capabilities at the University of Kentucky
• Collaborative environment: Partner with researchers across a wide range of disciplines
• Cutting-edge technology: Work with state-of-the-art mass spectrometry platforms and analytical tools
• Professional growth: Engage with national leaders, emerging technologies, and high-impact research programs
• UK’s Exceptional Benefits

Why Now? Proteomics is playing an increasingly important role in understanding complex biological systems, identifying therapeutic targets, and supporting translational research. As demand for advanced proteomics services continues to grow, the university is investing in the expertise and technologies needed to support next-generation research initiatives.