Scientist/Sr. Scientist, Bioinformatics Data

• Analyze diverse and large-scale genomic datasets (e.g., RNA-seq, scRNA-seq, WES/WGS, epigenetic, or multi-omics data) to identify biomarkers, therapeutic targets, or disease mechanisms.
• Apply advanced statistical, machine learning, and data-mining techniques to extract meaningful patterns from noisy biological data.
• Perform quality control, normalization, and batch-correction across heterogeneous datasets.
• Design, optimize, and maintain robust, scalable bioinformatics pipelines.
• Implement version-controlled code architectures to ensure reproducibility and scalability of data analyses.
• Procure and integrate existing biological databases with internal datasets.
• Translate complex computational and statistical findings into clear biological narratives for experimental biologists, clinicians, and stakeholders.
• Collaborate with IT and other functional groups., Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.

We are seeking a highly motivated, passionate, and driven Bioinformatics Data Scientist with high scientific curiosity to join our research and development team. In this role, you will bridge the gap between complex biological datasets and actionable therapeutic insights. You will design, develop, and execute scalable computational pipelines to analyze high-dimensional genomic data.The ideal candidate possesses a deep curiosity for biological systems, an analytical mindset, and the technical skillset to tackle unstructured, diverse and complex multiomics challenges. Whether you come from a deep biological background with strong computational skills or a data science background with a proven track record in working with biological data, you will play a critical role in accelerating both our discovery and clinical pipeline., * Ph.D. or M.S. in Bioinformatics, Computational Biology, Data Science, Genomics, Biology, or a highly quantitative field.

• Proven experience handling genomic data (Next-Generation Sequencing/NGS data analysis is required).
• Ability to turn raw biological data into structured insights.
• Strong experience with AI application in data science.
• Advanced proficiency in R (e.g., Bioconductor, Tidyverse) and/or Python (e.g., Pandas, NumPy, Scikit-learn).
• Experience with standard bioinformatics tools (e.g., alignment tools, variant callers, single-cell toolkits like Seurat/Scanpy).
• Experience with cloud computing platforms (AWS, GCP) and containerization (Docker, Singularity) is a strong plus.
• A self-starting attitude with an intrinsic desire to stay ahead of the curve in emerging computational methods and biological technologies.
• Proven ability to thrive in a fast-paced environment, manage multiple projects simultaneously, and pivot quickly based on data-driven feedback.
• Exceptional critical thinking skills with a knack for debugging complex code and parsing unstructured data formats.
• Creative, innovative and excellent communication and presentation skills.
• This role is designed as the starting point of group effort to solve complex biological and clinical problems in a fast paced environment. We look for individuals who take extreme ownership of their expertise and training, and driven by the prospect of turning data into information, and information into knowledge.

The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws.

Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles.

Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

Pay Range (Base Pay):

$127,313 - $167,099 USD

Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma., Legend Biotech was founded as an early-stage cell therapy company in 2014. The company was the brainchild of visionary scientists who recognized that antibody-based therapeutics could potentially treat disease and possessed the backgrounds in immunology and gene editing to take the leap.

For two years, Legend Biotech, then known as the “Legend Project,” operated in a room the size of a freight elevator, with the goal of creating a cell therapy for multiple myeloma, a hematological cancer that often relapses and can become refractory. The team produced nanobodies for single-domain antibody drugs and ultimately extended the half-life of the nanobodies with proprietary technologies.

In 2015, Legend’s scientists focused on research for chimeric antigen-receptor T-cells (CAR-T) targeting the BCMA protein, making the biotech one of the first companies in the world to engineer CAR-T cells for the BCMA protein. In 2016, investigator-initiated trials began in China.

In 2017, data from the trials were presented at the American Society for Clinical Oncology (ASCO), which led to a partnership with biopharmaceutical company Janssen Biotech, Inc. to co-develop the anti-BCMA CAR-T, ciltacabtagene autoleucel (cilta-cel). Applications seeking approval of cilta-cel for the treatment of patients with RRMM are currently under regulatory review by several health authorities around the world. CARVYKTI (ciltacabtagene autoleucel) was approved by the U.S. Food and Drug Administration in February 2022 and received conditional marketing approval from the European Medicines Agency in May 2022.

Today Legend Biotech is a global, commercial-stage company driven by a passion for patients. We continue to build our pipeline of cell therapy platforms, which includes CAR-T, CAR-NK, CAR-γδ T and non-gene-editing CAR technologies.

Our goal is to bring hope and opportunity to patients and their families by continuing to explore unique technologies.