Research Engineer/Postdoc - Bioinformatics and Data Analysis (M/F) H/F

Ciliopathies, a group of rare genetic diseases, result from primary cilium dysfunction and manifest in various severe disorders. TheRaCil project aims to enhance the diagnosis and prognosis of pediatric renal ciliopathy patients while implementing therapeutic approaches. The project involves a consortium of European partners leveraging unique databases and multi-omics data for patient stratification and identification of therapeutic targets., The recruited professional will play a crucial role in two key aspects of TheRaCil project:

• Genetic Modifiers of Renal Disease Onset:

• Replicate and expand upon WGS project on genetic modifiers of age at onset of ESKD ;
• Utilize genomics data within the consortium for further GWAS analyses, identifying new modifiers ;
• Study the functional impact of genetic modifiers through RNAseq experiments.

• Molecular Signatures of Therapeutic Interventions:

• Analyze scRNASeq and snRNASeq data from human cellular and mouse models to understand the impact of therapeutic interventions on molecular signatures ;
• Identify primary target cell populations, evaluate single-cell responses, and assess immune cell occurrence.

Do you have experience in Writing skills?, Do you have a Doctoral degree?, * Bioinformatic analyses of NGS data (WES, WGS, RNAseq) ;

• Statistical analyses of Omics data (GWAS, enrichment analysis, differential gene expression analysis) ;
• Knowledge of machine learning ;
• Familiarity with scRNA-seq data analysis ;
• General knowledge in genetics and molecular biology ;
• English proficiency (B2 to C1).

Operational Skills:

• Mastery of Unix/Linux environment and programming languages (Python, R) ;
• Proficiency in exome/genome analysis, including variants annotation and prioritization ;
• Knowledge of public genomic databases (NCBI, GenCode, gnomAD, Biomart, etc.) ;
• Data management skills for large-scale datasets ;
• Report writing and presentation skills in English and French., 2 to 5 years of research experience

Premier pôle européen de recherche, de soins et d'enseignement sur les maladies génétiques créé en 2007 au cœur du campus de l'Hôpital Necker-Enfants malades. Sa mission ? Mieux comprendre les maladies génétiques pour mieux les guérir. L'Institut Imagine est un endroit unique au monde qui rassemble chercheurs, patients, médecins et personnels de santé dans une architecture créatrice de synergies au service d'une même ambition : changer la vie des familles touchées par les maladies génétiques.